Chaoyong James Yang received his B.S. (1998) and M. S. (2001) from Xiamen University, China. He studied for this PhD in the Department of Chemistry at the University of Florida from 2001 to 2006. After completing his PhD dissertation, he conducted his postdoctoral research at the University of California, Berkeley. In 2008, he became a faculty member of Xiamen University and now is the Lu Jiaxi Professor of Chemistry in the Department of Chemical Biology at Xiamen University. He won a Chinese Government Award for Outstanding Students Abroad (2005) and is the recipient of American Chemical Society DAC Graduate Fellowship in 2005, CAPA Distinguished Faculty Award in 2012 and National Outstanding Young Investigator Award in 2013. His current research is particularly focused on molecular engineering, molecular recognition, high throughput evolution, single cell analysis and microfluidics.
Department of Chemical Biology, Xiamen University, Xiamen, 361005, China.
Over the last two decades, numerous functional nucleic acid probes including aptamers, riboswitches, ribozymes, and DNazymes have been discovered. The emergence of these functional nucleic acid probes has greatly changed our view on the role of nucleic acids in life processes-they are not only the carriers of genetic information, they can also function as enzymes and receptors. More importantly, these functional nucleic acid probes have found their wide applications in biomedicine including biomolecule sensing, biomarker discovery, drug screening, target delivery, gene regulation and disease diagnosis. In this talk, I will present some recent progress from our group on functional nucleic acid probe selection, optimization, structure modification and their applications in bioanalysis and biomedicine.
Keywords: functional nucleic acids, aptamers, DNAzymes, microfluidics