Invited Speakers

Microengineered Biomedical Devices for Precision Diagnosis and Medicine

Invited Session Chair: Ting-Hsuan Chen, City University of Hong Kong

Manipulation of microscale substance such as cells, microbeads, chemical drugs enables unprecedented accessibility for precision diagnosis and medicine. In this invited session, we provide a venue for discussing an array of devices for microengineered biomedical devices for investigation of biological research such as multiplex detection of exosomes, drug screening platform, cell research, and theranostics. It is anticipated to bring inspiration propelling researches with new perspectives.

Presentations:

  • Micro/Nano Biomedical Devices for Precision Diagnosis and Therapy, Gaobo Wang, Department of Biomedical Engineering, School of Medical Engineering, Henan Medical University, China (Invited)
  • Droplet-microarray Platform for Multiplex Detection of Exosomes, Yi Liu, Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong SAR (Invited)
  • Towards Precision Medicine: Small-scale Robots for Minimally Invasive Therapeutic Applications, Wenbin Kang, Department of Mechanical Engineering, City University of Hong Kong, Hong Kong SAR, China (Invited)
  • Be Water: Fluidity, Flow-Induced Mechanotransduction in Atherogenesis and Its Translational Studies, Wang Li, Department of Biomedical Sciences, City University of Hong Kong, Hong Kong, China (Invited)
  • Collective Cell Chirality Driven by Left-right Polarity of Epithelial Cells, Jianpeng Wu; Ting-Hsuan Chen, Department of Biomedical Engineering, City University of Hong Kong, Hong Kong Special Administrative Region, China (Invited)

Advances in Nanobiomaterials, Biosensing, and Biomedical Engineering

Invited Session Chair: Ting-Yu Liu, Department of Materials Engineering, Ming Chi University of Technology, New Taipei City 243303, Taiwan (Email: [email protected])

This session highlights recent advances in nanobiomaterials, biosensing, and biomedical engineering, with a focus on innovative materials and technologies for healthcare applications. The invited speakers will present their latest research on nanoparticle-based sensing platforms, flexible bioelectronics, antimicrobial biomaterials, conductive hydrogels, and nanohydroxyapatite for bone regeneration. The session will showcase how interdisciplinary approaches integrating materials science, nanotechnology, engineering, and biomedical research can address emerging challenges in disease detection, health monitoring, infection control, wound healing, and tissue regeneration. Participants will gain insights into cutting-edge developments and future opportunities in advanced biomaterials and biomedical technologies.

Presentations:

  • Nanoparticle arrays manufacturing for Electrochemical and Raman enhancing sensors in bio-detection, Ting-Yu Liu, Department of Materials Engineering, Ming Chi University of Technology, Taiwan (Invited)
  • Direct-Printed Flexible Microstructured sEMG Electrodes for Fatigue Monitoring, Ying-Chih Liao, Department of Chemical Engineering, National Taiwan University, Taiwan (Invited)
  • Eggshell-Derived Bio-calcium Material Drives Inactivation of Escherichia coli, Li-Ting Yen, Department of Safety, Health and Environmental Engineering, Ming Chi University of Technology, Taiwan (Invited)
  • Conductive Hyaluronic Acid Hydrogels for Electrical Stimulation and Wound Repair, Yu-Chun Chen, Department of Chemical Engineering, National United University, Taiwan (Invited)
  • Biofunctionalized Nanohydroxyapatite Restores Bone Homeostasis and Promote Regeneration in Compromised Microenvironments, Chi-Yun Wang, International Ph.D. Program in Innovative Technology of Biomedical Engineering and Medical Devices, Ming Chi University of Technology, Taiwan (Invited)

Micro/Nanoscale Engineering Platforms for Molecular Diagnostics and Therapeutics

Invited Session Chair: Megan Yi-Ping Ho, Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong; Department of Mechanical Engineering, National Taiwan University, Taiwan

Micro- and nanoscale engineering is transforming how disease is diagnosed and treated at the molecular level. This session assembles complementary advances spanning single-molecule analysis, droplet microfluidics for single-cell sequencing, point-of-care diagnostics, and stimuli-responsive therapy. Advances presented in this session include solid-state nanopores for label-free sequencing, light-responsive fluorosurfactants for programmable droplet operations, multi-parametric droplet sorting and merging for high-fidelity single-cell omics, reagent-free microfluidic detection of infectious pathogens, and ultrasound-activated platforms for localized drug delivery. Together, these contributions demonstrate how nanomaterials, microfabrication, and integrated device design converge to enhance the sensitivity, throughput, and precision of biomedical measurement and intervention.

Presentations:

  • Single Molecule Analysis with a Pyramidal Silicon Nanopore, Aaron Ho-Pui Ho, Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong (Invited)
  • Light-Responsive Fluorosurfactants for Droplet-Based Bio-Applications, Megan Yi-Ping Ho, The Chinese University of Hong Kong / National Taiwan University (Invited)
  • A Generalizable Microfluidic Platform Combining Multi-Parametric Droplet Sorting and Multi-Droplet Merging in Single-Cell Sequencing, Luoquan Li, Department of Biomedical Engineering, The Chinese University of Hong Kong, Hong Kong (Invited)
  • A Point-of-Care Pathogen Detection System Using Reagent-Free Nucleic Acid Purification, Levent Yobas, Hong Kong University of Science and Technology, Hong Kong SAR, China (Invited)
  • Deep Learning-Assisted Cytopathological Analysis for Assessing Tumor Content of Endobronchial Ultrasound Bronchoscopy-Guided Lung Biopsy, Yen-Liang Liu, Master Program of Biomedical Engineering, China Medical University, Taiwan (Invited)

Nanobiomaterials for Targeted Therapeutics and Regenerative Medicine

Invited Session Chair: Peggy Pik Kwan Lo, Department of Chemistry, City University of Hong Kong

This invited session showcases cutting-edge advancements in advanced nanobiomaterials and precision delivery systems for targeted therapeutics and regenerative medicine. Speakers will explore the mechanics of highly biocompatible, non-cationic nanoparticles, metal complexes, proteins, and self-assembled DNA/TNA nanostructures designed for intracellular drug delivery and genetic medicine. Complementing these intracellular strategies, the session highlights smart biomaterials—including extracellular vesicles, nanophotosensitizers, engineered living systems, and intelligent hydrogels—engineered to remodel hostile tissue microenvironments for cardiac repair. Together, these presentations illustrate how leveraging precise molecular design and microenvironmental regulation can overcome traditional therapeutic barriers, offering innovative, next-generation solutions for complex diseases and tissue regeneration.

Presentations:

  • Engineering Biomaterials for Myocardial Microenvironment Modulation and Cardiac Repair, Zhenhua Li, Department of Biomedical Engineering, Southern Medical University (Invited)
  • Non-cationic bionanomaterials for delivery to challenging diseased sites, Jonathan Chung Hang Choi, Department of Biomedical Engineering, The Chinese University of Hong Kong (Invited)
  • Development of Novel Nanophotosensitizers for Inducing Immunogenic Cell Death in Photodynamic Therapy, Pui-Chi Lo, Department of Biomedical Sciences, City University of Hong Kong (Invited)
  • Targeting Hypersialylation in Metastatic Cancer Cells using Lectin-directed Protein Aggregation Therapy (LPAT), Kenward Vong, Department of Chemistry, The Hong Kong University of Science and Technology (Invited)
  • Engineering of Nucleic Acids for Biomedical Applications, Peggy Pik Kwan Lo, Department of Chemistry, City University of Hong Kong (Invited)

Advanced Nanomedicine for Imaging, Therapy, and Regenerative Medicine

Invited Session Chair: Peilin Chen, Research Center for Applied Sciences, Academia Sinica, Taiwan

This invited session highlights emerging nanomedicine strategies that integrate smart materials, disease-responsive delivery, advanced imaging, and regenerative therapeutics. The presentations span gut-localized antioxidant nanoparticles for systemic inflammation, trigger-responsive peptidyl liposomes for smart MRI contrast, molecular blockade of inflammation-driven fibrosis, adipose stem cell-derived exosomes for skin rejuvenation, and advanced optical imaging for nanomedicine validation. Together, the session connects nanoparticle design, biological mechanism, therapeutic translation, and quantitative imaging to advance next-generation nanomedicine.

Presentations:

  • Intestinal ROS as an Upstream Driver of Systemic Inflammation: Therapeutic Potential of Gut-Localized Antioxidant Nanoparticles, Yukio Nagasaki, National Cheng Kung University, Taiwan / University of Tsukuba, Japan (Invited)
  • Peptidyl Liposome for Trigger-Responsive Delivery Vesicle and Smart MRI Contrast, Cheng-Bang Jian; Hsien-Ming Lee, Institute of Chemistry, Academia Sinica, Taiwan (Invited)
  • The Blockade of PTX3-CD44 Interaction Suppresses Keratinocyte and Fibroblast Activation in Pathological Scarring, Ju-Ming Wang, Department of Biotechnology and Bioindustry Sciences, National Cheng Kung University, Taiwan (Invited)
  • Next-Generation Regenerative Nanomedicine: Adipose Stem Cell-Derived Exosomes for Skin Rejuvenation, Hui-Min David Wang, Graduate Institute of Biomedical Engineering, National Chung Hsing University, Taiwan (Invited)
  • Validation of Nanomedicine by Advanced Imaging, Peilin Chen, Research Center for Applied Sciences, Academia Sinica, Taiwan (Invited)

Microfluidics and Materials in Biomedical Application

Invited Session Chair: Yu-Jui (Ray) Fan, Department of Mechanical Engineering, National Yang Ming Chiao Tung University, Taiwan

As modern healthcare demands higher precision and efficiency, the integration of cutting-edge microfluidics with novel functional materials has opened unprecedented frontiers in biomedicine. The key scientific advancements in this session have presented next-generation concepts related to microfluidics and biomaterials. Use of properly designed and structured microfluidics and materials allows for the development of well-defined sensing prototypes that support a series of directed events.

Presentations:

  • Fabrication of TiO2 / SS316L composite coating by digital light processing for photoelectrochemical degradation of organic pollutants, Jui-Ting Liang, Department of Mechanical and Electro-Mechanical Engineering, National I-lan University, Taiwan (Invited)
  • Template-assisted ZnO nanorod array fabrication and applications, Shih-Hsun Chen, Department of Mechanical Engineering, National Yang Ming Chiao Tung University, Taiwan (Invited)
  • Microfluidic Isolation of Functional Mitochondria for Bioenergetic Restoration in Hypoxia-Injured and Senescent Cells, Han-Yun Hsieh, National Dong Hwa University, Taiwan (Invited)
  • Nanofluidic Reactor with Glass Nanofluidic Device Fabrication, Kyojiro Morikawa, Department of Power Mechanical Engineering, National Tsing Hua University, Taiwan (Invited)
  • Integration of Preconcentration Chip with the Field Effect Transistor (FET) Biosensor for biomarker detection, Yu-Jui Fan, National Yang Ming Chiao Tung University, Taiwan (Invited)

Frontier Interdisciplinary Symposium on Micro-Nano and Biomedical Systems

Symposium Chair: Prof. Wen J. Li, City University of Hong Kong

This symposium aims to present cutting-edge achievements at the intersection of micro-nano systems, biomolecular sensing, and medical robotics. The content spans from foundational micro-nano manufacturing of high-precision IMUs for autonomous driving to innovative breakthroughs in biomedical diagnostics. In the realm of life sciences and basic research, the sessions introduce solid-state subnanopores for single-molecule protein sequencing, organoid-on-paper platforms mimicking tumor and bone tissue microenvironments, and embodied virtual cell robotic systems exploring collective cellular behaviors. At the clinical and diagnostic level, the symposium delves into small-scale robotics for gastrointestinal theranostics, sensor-actuator integration in microrobots, single-cell biosensing for rapid sepsis diagnosis, and the quantitative characterization of human meridian thermal rhythms using infrared thermography.

Presentations:

  • Full-length Protein Classification through Sequence Reading by Solid-State Subnanopores, Zhuxin Dong, Central South University (Invited)
  • Development of Organoid-on-Paper Platform: Mimicking Tumor and Bone Tissue Microenvironment, Kin Fong Lei, Chang Gung University (Invited)
  • Small-scale robotics for gastrointestinal diseases diagnosis and treatment, Na Liu, Shanghai University (Invited)
  • High-Precision Integration of Micro-Nano Six-Axis Inertial Measurement Chipset via Deep Silicon Etching and Wafer-Level Packaging, Guangyi Shi, Peking University (Invited)
  • Single Cell Biosensing for Rapid Diagnosis of Sepsis and Multidrug-Resistant Infections, Pak Kin Wong, The Pennsylvania State University (Invited)
  • Embodied Virtual Cell: A Robotic Platform Exploring the Physical Principles of Cell Collective Behaviors, Yongliang Yang, Shenyang Institute of Automation, Chinese Academy of Sciences (Invited)
  • Design and Realization of Microrobot Sensor-Actuator Integration, Yuzhao Zhang, Shanghai University (Invited)
  • Quantitative Characterization of Human Meridian Thermal Rhythms Using Infrared Thermography, Yuliang Zhao, Northeastern University at Qinhuangdao (Invited)

Convergent Nanomedicine Platforms for Precision Sensing and Therapeutic Innovation

Invited Session Chair: Yu-Jung Lin, Research Center for Applied Sciences, Academia Sinica, Taiwan

This session highlights nanoplasmonic biosensing, 2-D nanomaterials, microfluidic microenvironment control, localized hydrogen generation, and automated synthesis. Together, these technology platforms enable sensitive real-time biomolecular detection, physiologically relevant disease modeling, spatially controlled immunomodulation, and reproducible therapeutic reagent formulation. 2-D nanomaterials have intrinsic potential for ultrasensitive molecular interaction interrogation, while nanoplasmonic sensing supports high-throughput biomarker detection. Microfluidic platforms provide deeper mechanistic insights by recapitulating complex cellular microenvironments. ECM-targeted hydrogen generation offers a precision strategy for modulating immune microenvironments. Integrated with these platforms, automated synthesis further accelerates optimization, scalability, and translation.

Presentations:

  • Microcavity Lasers with Two-Dimensional Semiconductors for Practical Applications, Min-Hsiung Shih, Research Center for Applied Sciences, Academia Sinica, Taiwan (Invited)
  • Microfluidic Cell Culture and Analysis: Better Models, Deeper Insights, Yi-Chung Tung, Research Center for Applied Sciences, Academia Sinica, Taiwan (Invited)
  • ECM-Targeted Hydrogen-Generating Nanomedicine for Precision Immunomodulation, Yu-Jung Lin, Research Center for Applied Sciences, Academia Sinica, Taiwan (Invited)
  • Development of Automated Chemical Synthesis System, Shu-Yi Hsieh, Research Center for Applied Sciences, Academia Sinica, Taiwan (Invited)

From Paper Microfluidics to Single Molecule

Invited Session Chair: Zhugen Yang, Cranfield University, UK

This session explores the paradigm shift from paper-based microfluidics to single-molecule detection for health and environmental surveillance. Converging advances in CRISPR/Cas amplification-free detection, wearables, portable diagnostics, and microfluidic single-cell isolation are enabling this frontier. Speakers will present breakthroughs in nucleic acid detection and translation to real-world applications, highlighting chemical biology and engineering biology’s role in bridging fundamental discoveries with deployable technologies.

Presentations:

  • Measurements of molecular size and shape on a chip, Xin Zhu, College of Information Science and Electronic Engineering, Zhejiang University, China (Invited)
  • Portable Multiplex Protein Detection Using MagPEA-POCT, Tianyi Liu, Johns Hopkins University, USA (Invited)
  • New functionalities in lateral flow platforms for digital health point-of-care DNA diagnostics, Julien Reboud, University of Glasgow, UK (Invited)
  • A 3D Origami Paper Microfluidic Platform for Non-invasive Multi-biomarker Monitoring in Sweat, Bo Liang, Zhejiang University, China (Invited)
  • Origami-Paper Device for Point-of-Care Diagnostics, Zhugen Yang, Cranfield University, UK (Invited)

Next-Generation Biosensing, Imaging and Lab-on-a-Chip Platforms

Invited Session Chair: Jyong-Huei Lee, Department of Engineering Science and Ocean Engineering & Global Undergraduate Program in Semiconductors, National Taiwan University, Taiwan

This session focuses on emerging biosensing, imaging, and lab-on-a-chip technologies that enable rapid, quantitative, and functional phenotyping analysis. Topics include continuous metabolic phenotyping for long-term cell culture, portable optical imaging systems for early cancer screening and diagnosis, liver tumor labchips for drug resistance studies, digital microfluidics for programmable droplet generation, and multimodal biosensor design workflows empowered by DNA language models for precision diagnostics.

Presentations:

  • Continuous Metabolic Phenotyping for Long-Term Cell Culture: From Snapshot Assays to Dynamic Cellular Insights, Cheng-Han (Charles) Tsai, Leadgene Biosolutions co, Ltd / National Taiwan University, Taiwan (Invited)
  • Portable Optical Imaging Systems for Early Cancer Screening and Diagnosis, Wibool Piyawattanametha, King Mongkut’s Institute of Technology Ladkrabang (KMITL), Thailand / Michigan State University, USA (Invited)
  • Liver Tumor Labchip with Oxygen-concentration Regulation for Exploring Hypoxia-induced Drugs Resistance, Yeh-Hao Tseng; Cheng-Hsien Liu, National Tsing Hua University, Taiwan (Invited)
  • Frequency-Controlled Multiple Droplet Generation on Digital Microfluidics Chip, Yen-Wen Lu, Department of Biomechatronics Engineering, National Taiwan University, Taiwan (Invited)
  • Multimodal Biosensors and DNA Language Models for Precision Clinical Diagnostics, Jyong-Huei Lee, National Taiwan University, Taiwan (Invited)

Sustainable Nanomaterials and Intelligent Engineering for Biointerfaces and Energy Systems

Session Chair: Da-Jeng Yao, National Tsing Hua University, Hsinchu, Taiwan

This session explores emerging materials and data-efficient engineering strategies for sustainable, high-performance technologies. Topics include biomass-derived porous carbon electrodes for long-life energy storage, plasma-synthesized biocompatible conductive polymers for neural interfaces, and Complex-System-Response modeling for efficient multi-parameter optimization. Together, these studies demonstrate how green synthesis, multifunctional nanomaterials, and intelligent process design can accelerate innovation across bioelectronics, advanced manufacturing, biomanufacturing, and energy systems.

Presentations:

  • Biocompatible Conductive PEDOT Synthesized by Nonthermal Plasma: A Green Alternative for Neural Interface Applications, Yesong Gu, Meng-Tsun Lai, Pei-Kang Gu, Tunghai University / Polink Advanced Materials Co., Ltd., Taiwan (Invited)
  • Advanced Carbon Nanomaterials and Single-Atom Catalysts for Sustainable Nanomedicine and Bioelectronics, Yu-Hsien Liao, Jarrn-Horng Lin, National University of Tainan / National Tsing Hua University, Taiwan (Invited)
  • A Complex-System-Response (CSR) Approach to Efficient Multi-Parameter Optimization in Engineering and Biomanufacturing, Yi-Ju Liu, Da-Jeng Yao, Chih-Ming Ho, National Tsing Hua University, Taiwan (Invited)

Nanoconvergence-based Cancer Research: Nanoplasmonic, Microfluidic Chip, Biomimetic Nanovesicles, and Tumor Imaging Platforms

Invited Session Chair: Joon Myong Song, College of Pharmacy, Seoul National University, South Korea (Email: [email protected])

This session introduces various cancer studies based on nanoconvergence. An innovative nanoplasmonics–microfluidic platform that employs dual biomarker-specific plasmonic nanotags to label exosomal surface markers shows highly specific liquid-biopsy approaches for early cancer detection. The microfluidic chip systems suggest the effect of microenvironmental structure and spatial heterogeneity in infectious diseases and cancer. An exosome study shows discovery of functionally active exosomes, fabrication of scalable biomimetic nanovesicles, and AI-guided design of next-generation nanotherapeutics. The tumor transparency imaging study introduces how drug permeability and the anticancer effect of nano drug carriers are affected by intratumoral vascular damage.

Presentations:

  • Advanced Nanoplasmonic Platforms for In Vitro Diagnostics: Pathways to Clinical Translation, Jaebum Choo, Department of Chemistry, Chung-Ang University, Seoul, South Korea (Invited)
  • Evolutionary Dynamics of Viral Transmission and Cancer Drug Resistance on Microfluidic Chip Platforms, Sungsu Park, Sungkyunkwan University, Suwon, South Korea (Invited)
  • AI-guided engineering of biomimetic nanovesicles: from natural exosomes to scalable smart nanotherapeutics, Hyo-Il Jung, Yonsei University, South Korea (Invited)
  • Drug Permeability and Anticancer Effect of Nano Drug Carriers Depending on Intratumoral Vascular Damage, Joon Myong Song, College of Pharmacy, Seoul National University, South Korea (Invited)