Plasma-assisted multiscale topographic scaffolds for soft and hard tissue regeneration
Jangho Kim
Department of Rural and Biosystems Engineering, Chonnam National University, Gwangju, Republic of Korea (E-mail: rain2000@jnu.ac.kr)
Abstract
The design of transplantable scaffolds for tissue regeneration requires gaining precise control of topographical properties. Here, we propose a methodology to fabricate hierarchical multiscale scaffolds with controlled hydrophilic and hydrophobic properties by employing capillary force lithography in combination with plasma modification. Using our method, we fabricated biodegradable biomaterial (i.e., polycaprolactone (PCL))-based N2 gas (N-FN) and O2 gas plasma-assisted flexible multiscale nanotopographic (O-FMN) patches with natural extracellular matrix-like hierarchical structures along with flexible and controlled hydrophilic properties. In response to multiscale nanotopographic and chemically modified surface cues, the proliferation and osteogenic mineralization of cells were significantly promoted. Furthermore, the O-FMN patch enhanced regeneration of the mineralized fibrocartilage tissue of the tendon–bone interface and the calvarial bone tissue in vivo in rat models. Overall, the PCL-based O-FMN patches could acceleratesoft and hard tissue regeneration. Thus, our proposed methodology was confirmed as an efficient approach for the design and manipulation of scaffolds having a multiscale topography with controlled hydrophilic property.
Short Bio
Dr. Jangho Kim is an Associate Professor of Biosystems Engineering and a Director of Center for IT-Bio Convergence System Agriculture at Chonnam National University. Prior to joining the current position, he studied as a Senior Researcher of the Research Institute for Agriculture and Life Sciences, Seoul National University. He also studied as a Researcher in the Thin Film & Charged Particles Research Laboratory at Department of Electrical and Computer Engineering, University of Illinois at Urbana-Champaign. His research interests include 1) biomaterials and biofabrication, 2) biologically inspired engineering systems, 3) cell and tissue engineering, and 4) agricultural micro- and nanotechnology. He has published over 110 peer-reviewed journal publications, over 30 invited presentations, and over 10 patents pending or granted. He has received many research awards such as Young Scientist Award (Korean and Japan Society for Biomaterials, 2012), Young Plenary Speaker (TERMIS-AP conference, 2013), Samsung HumanTech Paper Award (Samsung Electronics, 2014), Keynote Speaker (TERM STEM 2014), Promising Young Scientist (Korean Society of Mechanical Engineers, 2016), and Excellent Young Professor Award (Chonnam National University, 2017). He has served as organizing committees for several international conferences as well as editorial member for several journals including associate editor of Engineering in Agriculture, Environment and Food (Elsevier).