Implantable SERS Device for Glucose Detection
Daejong Yang
Department of Mechanical and Automotive Engineering, Kongju National University, Republic of Korea
Department of Future Convergence Engineering, Kongju National University, Republic of Korea
daejong@kongju.ac.kr
Abstract
Diabetes is a chronic disease, 463 million patients in the world suffer from it in 2019. That means one in 11 adults has diabetics. In order to prevent complications, continuous glucose monitoring is the most effective and simple method to control the glucose level. However, patients are feeling reluctant to draw blood several times a day. Many methods have been developed to alleviate the pain, and we would like to introduce a novel non-invasive measurement for glucose level sensing by using surface-enhanced Raman-scattering (SERS). We have developed a high-sensitive and uniform SERS substrate consisting of 3D stacked gold nanoparticle clusters. The substrates were fabricated by the hydrothermal synthesis of ZnO nanowire template and repeated liquid phase deposition of Au nanoparticles. To connect glucose molecules and the SERS substrate mercaptophenylboronic acid (MPBA) was coated on the substrate to act as a linker molecule. Bonding of glucose to MPBA suppresses the breathing mode of MPBA and promotes the constrained-bending mode. Due to the vibration mode change, the most dominant SERS peak of MPBA located at 1071 cm-1 moves toward larger wavenumbers. The SERS-peak shifts mechanism was analyzed by numerical simulations based on density functional theory and verified by experimental measurement. We have implanted the SERS disk in the anterior chamber of rabbit eyes and successfully measured glucose concentration in aqueous humor.
Short Bio
Daejong Yang is an Assistant Professor in the Department of Mechanical and Automotive Engineering and the Department of Future Convergence Engineering at Kongju National University in the Republic of Korea since 2018. He is a member of the board of directors of the IT Convergence division, Korean Society of Mechanical Engineers (KSME). He researched flexible sensor devices based on nanomaterials in the Department of Nanoengineering at the University of California, San Diego (UCSD) from 2014 to 2015 and also researched optical biosensors in the Department of Medical Engineering at the California Institute of Technology (Caltech) from 2015 to 2018. Based on these researches, his research group has developed novel fabrication methods for 0 and 1-dimensional nanomaterials for applications in bio and chemical sensors.