Precise capture and dynamic relocation of nanoparticulate biomolecules through dielectrophoretic enhancement by vertical nanogap architectures
Yong-Sang Ryu, Senior researcher
Sensor System Research Center, Korea Institute of Science and Technology
ysryu82@kist.re.kr
Abstract
Toward the development of surface-sensitive analytical techniques for biosensors and diagnostic biochip assays, a local integration of low-concentration target materials into the sensing region of interest is essential to improve the sensitivity and reliability of the devices. As a result, the dynamic process of sorting and accurate positioning the nanoparticulate biomolecules within pre-defined micro/nanostructures is critical, however, it remains a huge hurdle for the realization of practical surface-sensitive biosensors and biochips. A scalable, massive, and non-destructive trapping methodology based on dielectrophoretic forces is highly demanded for assembling nanoparticles and biosensing tools. Herein, we propose a vertical nanogap architecture with an electrode-insulator-electrode stack structure, facilitating the generation of strong dielectrophoretic forces at low voltages, to precisely capture and spatiotemporally manipulate nanoparticles and molecular assemblies, including lipid vesicles and amyloid-beta protofibrils/oligomers. Our vertical nanogap platform, allowing low-voltage nanoparticle captures on optical metasurface designs, provides new opportunities for constructing advanced surface-sensitive optoelectronic sensors.
Short Bio
Yong-Sang Ryu is a Senior Researcher in Sensor System Research Center, Korea Institute of Science and Technology (KIST). He received his first B.S./M.S./Ph.D degrees in Electrical and Computer engineering department from Seoul National Univ. He was a Postdoctoral researcher in Electrical and Computer engineering department in University of Minnesota, Twin Cities, U.S.A for 3 years and moved to Korea Institute of Science and Technology (KIST) from 2016.
His research focus is in the area of Bio/Nano Technology including designed of device platform/chip via nano/biochip fabrication, simulation, detection, & analyzation for nano/bio material using optical/electrical instrument. He is an young scientist trying to mix and converge the IT-NS and bio-med fields.